tweakv. t.[OE. twikken, originally the same word as twicchen; cf. LG. twikken. See Twitch.] To pinch and pull with a sudden jerk and twist; to twitch; as, to tweak the nose.(Shak.)n.1. A sharp pinch or jerk; a twist or twitch; as, a tweak of the nose.(Swift.)2. Trouble; distress; tweag.()3. A prostitute.(Brathwait.)