cayennen.[From Cayenne, a town and island in French Guiana, South America.] Cayenne pepper.()Cayenne pepper. (a) (Bot.) A species of Capsicum (Capsicum frutescens) with small and intensely pungent fruit. (b) A very pungent spice made by drying and grinding the fruits or seeds of several species of the genus Capsicum, esp. Capsicum annuum and Capsicum Frutescens; -- called also red pepper. It is used chiefly as a condiment.()